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NantKwest doses first patient in Phase 2 Merkel cell carcinoma study

NantKwest

NantKwest (NASDAQ:NK) dosed the first patient in its Phase 2 trial for second- and third-line Merkel cell carcinoma (MCC).

MCC is a rare and aggressive skin cancer that is fatal for the majority of patients who have progressed on, or after, treatment with a checkpoint inhibitor.

The study will assess NantKwest’s off-the-shelf CD16-targeted natural killer cells – in combination with ImmunityBio’s IL-15 superagonist N-803 and Avelumab – in 43 patients who failed all standard-of-care treatments for MCC, including checkpoint therapy.

“With over 70% of patients failing checkpoint inhibitors in solid tumors, it is vital to develop novel and effective therapeutic options,” Dr. Patrick Soon-Shiong, chairman and CEO of NantKwest and ImmunityBio, said in a statement.

“Our combination therapy is designed to activate the innate immune system to create an immunological memory against tumors, resulting in immunogenic cell death,” he added.

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