Klotho Neurosciences (NASDAQ: KLTO) has announced that IP Australia has accepted 18 claims within its patent application covering the composition and use of its human secreted Klotho protein, s-KL isoform.
The patent, licenced from Universitat Autonoma de Barcelona, relates to the use of a human muscle-cell specific promoter linked to a nucleic acid sequence encoding human s-KL for the treatment of motor impairment.
In a statement, Dr. Joseph Sinkule, founder and CEO of Klotho, commented, “These claims are an important expansion of our patent estate, which we believe will help to provide momentum and security to pursue the therapeutic replacement or supplementation of human Klotho levels. As people age, they naturally lose innate, in vivo therapeutic concentrations of Klotho due to the commonly occuring DNA methylation of the promoter and gene leading to the ‘silencing’ of the Klotho gene in neuromuscular (motor neuron) cells and tissues in our body. The ‘method of use’ component of these claims includes treatment, wherein the subject has a disease or disorder characterized by motor impairment, such as a neuromuscular or motor neuron disease. We believe our approach to utilizing s-KL protein is a significant innovation and we look forward to continuing to develop our capabilities around addressing Klotho supplementation, and to providing updates as they emerge.”
