Closely held MOBILion Systems has announced its participation in the 21st annual US HUPO conference this month in Philadelphia. The company will showcase its new Parallel Accumulation with Mobility Aligned Fragmentation (PAMAF) operating mode through multiple presentations to demonstrate the increased speed and sensitivity of LC-MS analysis for proteomics applications.
According to MOBILion, researchers will demonstrate how PAMAF’s capabilities extend beyond traditional LC-MS approaches, highlighting how it reduces chimeric spectra to improve protein quantification and post-translational modification analysis.
In a statement, Melissa Sherman, Ph.D., CEO of MOBILion commented, “Our PAMAF operating mode enables researchers to make more accurate analytical measurements and achieve deeper proteome characterization, supporting scientific discovery in critical areas of human health research.”
Dr. Sherman added, “By replacing quadrupole isolation with high-resolution ion mobility separation, PAMAF generates fragmentation data with 10x higher signal-to-noise and 5x faster speeds than conventional systems. With essentially 100 percent ion utilization, PAMAF is particularly valuable for sample-limited workflows, including single-cell proteomics applications. MOBILion’s participation at US HUPO 2025 reflects our commitment to advancing proteomics research through innovative separation science.”
Scientific Program Details:
Oral Presentation (Tuesday, February 25, Session #11 – Emerging Opportunities in Proteomics, 1:40 PM – 3:00 PM):
- Abandoning the Quadrupole for MS Fragmentation Analysis: Towards 1,000 Hz Speeds with 100% Ion Utilization Using High Resolution Ion Mobility Precursor Isolation – Daniel DeBord, Ph.D., CTO at MOBILion
Poster Session 1 (Monday, February 24, 4:30 PM – 6:00 PM):
- P01.45LB: Characterization of Key Performance Figures of Merit for PAMAF in Proteomics Applications
Poster Session 2 (Tuesday, February 25, 4:30 PM – 6:00 PM):
- P05.26LB: Leveraging HRIM for Dual-purpose Feature Definition and Alignment: Validation of Proteomics Workflows for PAMAF Data
- P08.08LB: A Novel All-Ion Parallel Reaction Monitoring (AI-PRM) methodology for Enhanced Sensitivity and Speed in High Throughput Targeted Proteomics Analysis
Educational Breakfast Seminar (Wednesday, February 26, 7:15 AM – 8:15 AM):
- High Resolution Ion Mobility for Next Generation Proteomics Analysis – Danel DeBord, Ph.D.
- Detection of Upregulated Succinylated Peptides from Sirtuin 5 Knockout Mice – Birgit Schilling, Ph.D.
MOBILion is exhibiting at booth number 18 and inviting attendees to learn how MOBILion’s PAMAF operation mode is shaping the future of proteomics.
